Skeletal ligament healing using the recombinant human amelogenin protein
نویسندگان
چکیده
منابع مشابه
Skeletal ligament healing using the recombinant human amelogenin protein
Injuries to ligaments are common, painful and debilitating, causing joint instability and impaired protective proprioception sensation around the joint. Healing of torn ligaments usually fails to take place, and surgical replacement or reconstruction is required. Previously, we showed that in vivo application of the recombinant human amelogenin protein (rHAM(+)) resulted in enhanced healing of ...
متن کاملHigh yield of biologically active recombinant human amelogenin using the baculovirus expression system.
The amelogenins are secreted by the ameloblast cells of developing teeth; they constitute about 90% of the enamel matrix proteins and play an important role in enamel biomineralization. Recent evidence suggests that amelogenin may also be involved in the regeneration of the periodontal tissues and that different isoforms may have cell-signalling effects. During enamel development and mineraliza...
متن کاملOne-Step Purification of Recombinant Human Amelogenin and Use of Amelogenin as a Fusion Partner
Amelogenin is an extracellular protein first identified as a matrix component important for formation of dental enamel during tooth development. Lately, amelogenin has also been found to have positive effects on clinical important areas, such as treatment of periodontal defects, wound healing, and bone regeneration. Here we present a simple method for purification of recombinant human amelogeni...
متن کاملRegeneration of bone and periodontal ligament induced by recombinant amelogenin after periodontitis
Regeneration of mineralized tissues affected by chronic diseases comprises a major scientific and clinical challenge. Periodontitis, one such prevalent disease, involves destruction of the tooth-supporting tissues, alveolar bone, periodontal-ligament and cementum, often leading to tooth loss. In 1997, it became clear that, in addition to their function in enamel formation, the hydrophobic ectod...
متن کاملExpression of Recombinant Human Amelogenin in Iranian Lizard Leishmania and Its Biological Function Assay
BACKGROUND Amelogenins are the major components of enamel matrix proteins. Enamel matrix derivatives (EMD) can be used in periodontal diseases to regenerate periodontal tissues. The main aim of this study was to evaluate expression of full-length functional recombinant human amelogenin (rhAm) in Iranian lizard Leishmania (I.L.L.) as an alternative eukaryotic expression system. METHODS Human c...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2016
ISSN: 1582-1838,1582-4934
DOI: 10.1111/jcmm.12762